"I-Baking Soda (iSodium Bicarbonate) engeyona enobuthi futhi engenabungozi ifakwe ku-nano 'capsule' ephephile (i-liposome), kanti i-tetracycline enamandla okubopha amathambo ibekwe ngaphezulu ukuze ikhangise ebusweni bethambo. Lapho ama-osteoclast echitha ithambo ngokufihla i-asidi, bangakhipha ngokushesha iSodium Bicarbonate, okuvimbela ukusebenza kwama-osteoclast nokufeza umgomo wokuvimbela i-osteoporosis ngokuyisisekelo. ” Ithimba eliholwa nguSolwazi Shunwu Fan woMnyango Wezamathambo, iRun Run Shaw Hospital, iZhejiang University, noSolwazi Ruikang Tang woMnyango Wezamakhemikhali, eZhejiang University, basanda kushicilela abakutholile kwiJenali ye-American Chemical Society.
Ngokwesingeniso, ama-osteoclasts afana nomuhlwa esihlahleni, owake wasebenza, ngisho nesihlahla esikhulu, kodwa futhi ngenxa yokubola nokuwa kwesikhathi eside. Ucwaningo lwamanje lukholelwa ukuthi imbangela eyinhloko ye-osteoporosis ukusebenza okungavamile kwama-osteoclasts, futhi ukuvinjelwa kwe-acid ngama-osteoclasts kubhekwa njengesici sokuqala sokubhujiswa kwamathambo ngama-osteoclasts kanye nemfuneko edingekayo yokwehliswa kwezicubu zethambo.
Izidakamizwa eziyinhloko ekwelashweni kwemitholampilo ye-osteoporosis zifeza inhloso ye-anti-bone resorption kanye nokukhuthaza i-bone anabolism ngokugxila ekulawulweni kwe-osteoclast noma i-osteoblast biology, kepha azibulali isinyathelo sokuqala esibalulekile semvelo ye-asidi yangaphandle yokwakheka kwe-osteoclast kusuka umthombo. Ngakho-ke, izidakamizwa ezikhona zinganciphisa ukulahleka kwethambo kubantu asebekhulile ngezinga elithile, kepha imvamisa azikwazi ukukuguqula ngokuphelele ukubhujiswa kwethambo okwenzekile, futhi ukuphathwa okukhethiwe kwemithi engeyona eyamathambo nakho kungaholela ekuthini kubhekiswe kokunye kanye neminye imiphumela emibi enobuthi yezitho.
Ngaphezu kwalokho, yize ama-osteoclast ayimbangela ye-osteoporosis, ucwaningo oluningi lukhombisile ukuthi lubamba iqhaza ekukhuthazeni ukwakheka kwamathambo kanye ne-angiogenesis "njengamaseli wangaphambilini" ngaphambi kokukhipha i-asidi. Ngakho-ke, kubaluleke kakhulu ukuvimbela ngokunembile ama-osteoclasts.
Ithimba likaFan Shunwu nethimba likaTang Ruikang liphayone ekuqondisweni kwe-Sodium Bicarbonate liposomes emathanjeni, kwakha ungqimba lwe-alkaline oluvikelayo, lwanciphisa i-asidi ekhishwe ama-osteoclast, ukuvimbela ukwenziwa okungajwayelekile kwama-osteoclast, nokwakha kabusha ibhalansi ye-bone microenvelo ukufeza umphumela wokwelapha i-osteoporosis .
U-Lin Xianfeng, udokotela ohlinzayo wamathambo e-Run Run Shaw Hospital yase-Zhejiang University, uthe lolu cwaningo luthole ukuthi izinto ezinama-alkaline liposome kanye nemvelo ye-acidic yama-osteoclast idale inani elikhulu le-apoptosis yama-osteoclast, futhi yaqhubeka yakhipha inani elikhulu lama-vesicles angaphandle kwamaseli. "Kufana neqoqo lama-domino, aqhutshwa ungqimba olulodwa ngasikhathi sinye futhi akhulise isinyathelo ngasinye ngesikhathi ukumelana ngokuphelele nokuqothulwa kwamathambo okubangelwa ukuqiniswa kwama-osteoclast."
Isikhathi Iposi: Jan-27-2021