“I-Baking Soda (i-Sodium Bicarbonate) engenabungozi futhi engenabungozi ihlanganiswe ku-nano 'capsule' ephephile (i-liposome), kanti i-tetracycline enamandla okubopha amathambo ifakwe ebusweni ukuze inamathele ebusweni bamathambo. Lapho ama-osteoclast ebhubhisa izicubu zamathambo ngokukhipha i-asidi, angakhipha i-Sodium Bicarbonate ngokushesha, avimbele ukusebenza kwama-osteoclast futhi afeze umgomo wokuvimbela i-osteoporosis ngokuyisisekelo.” Ithimba eliholwa nguSolwazi Shunwu Fan woMnyango Wezamathambo, iRun Run Shaw Hospital, iZhejiang University, kanye noSolwazi Ruikang Tang woMnyango Wezamakhemikhali, iZhejiang University, muva nje bashicilele okutholakele kwabo ku-Journal of the American Chemical Society.
Ngokwesingeniso, ama-osteoclast afana nezintuthwane esihlahleni, uma sezisebenza, ngisho nomuthi omude, kodwa futhi ngenxa yokubola nokuwa kwesikhathi eside. Izifundo zamanje zikholelwa ukuthi imbangela eyinhloko ye-osteoporosis ukusebenza okungavamile kwama-osteoclast, futhi ukukhishwa kwe-asidi ngama-osteoclast kubhekwa njengesici esiyinhloko sokubhujiswa kwamathambo ngama-osteoclast kanye nemfuneko edingekayo yokuwohloka kwezicubu zamathambo.
Imithi eyinhloko ekwelapheni i-osteoporosis emtholampilo ifezekisa inhloso yokumuncwa kwamathambo futhi ikhuthaze i-anabolism yamathambo ngokugxila ekulawulweni kwe-osteoclast noma i-osteoblast biology, kodwa ayibulali isinyathelo sokuqala esibalulekile sendawo yangaphandle ye-asidi yokwakheka kwe-osteoclast kusuka emthonjeni. Ngakho-ke, imithi ekhona inganciphisa ukulahleka kwamathambo kubantu asebekhulile ngezinga elithile, kodwa ngokuvamile ayikwazi ukuguqula ngokuphelele ukubhujiswa kwamathambo okwenzekile, futhi ukuphathwa okukhethekile kwemithi engeyona ithambo nakho kungaholela emiphumeleni emibi engeyona eyomuntu kanye neminye enobuthi yezitho zomzimba.
Ngaphezu kwalokho, yize ama-osteoclast eyimbangela ye-osteoporosis, izifundo eziningi zikhombisile ukuthi adlala indima ekukhuthazeni ukwakheka kwamathambo kanye ne-angiogenesis “njengamaseli angaphambi kokukhishwa” ngaphambi kokukhipha i-asidi. Ngakho-ke, kubaluleke kakhulu ukuvimbela ama-osteoclast ngokunembile.
Ithimba likaFan Shunwu kanye nethimba likaTang Ruikang bahola ekuqondisweni kwama-liposome e-Sodium Bicarbonate ebusweni bamathambo, bakha ungqimba oluvikelayo lwe-alkaline, banciphisa i-asidi ekhishwa ama-osteoclast, bavimbela ukusebenza okungavamile kwama-osteoclast, futhi bashintsha ibhalansi ye-microenvironment yamathambo ukuze kufezwe umphumela wokwelapha i-osteoporosis.
ULin Xianfeng, udokotela ohlinzayo wamathambo e-Run Run Shaw Hospital e-Zhejiang University, uthe lolu cwaningo luthole ukuthi izinto ze-alkaline liposome kanye nendawo ene-acidic yendawo yama-osteoclast kwabangela inani elikhulu le-apoptosis yama-osteoclast, futhi kwaphinde kwakhulula inani elikhulu lama-vesicle angaphandle. "Kufana nesethi yama-domino, acindezelwa ungqimba olulodwa ngesikhathi futhi akhuliswe isinyathelo esisodwa ngesikhathi ukuze amelane ngokuphelele nokubhujiswa kwamathambo okubangelwa ukuqina kwama-osteoclast."
Isikhathi sokuthunyelwe: Jan-27-2021